Merrill Goodman

Functional lab testing is advanced biomarker testing designed to find root causes and subtle imbalances that routine annual labs often miss. It is worth pursuing if you have unresolved fatigue, gut symptoms, hormone shifts, or “normal” bloodwork that doesn’t match how you feel. The single most important thing to understand before you order anything is this: functional testing interprets your results against tighter, function-focused “optimal” ranges, not the wide reference ranges your standard lab uses to flag disease. That distinction changes everything about what a test can tell you. A routine panel asks, “Is this person sick?” A functional panel asks, “Where is this person’s biology drifting before it becomes a diagnosis?” Comprehensive functional panels typically run 50 to 150 or more biomarkers in a single draw, covering everything from micronutrient status to hormone metabolites. Specialty tests like the DUTCH hormone pa...

Certain beta glucans, specifically yeast and fungal β-1,3/1,6 forms, can prime your innate immune system by binding to receptors called Dectin-1 and CR3, triggering a cascade that makes macrophages, monocytes, and neutrophils more responsive to future threats. The strongest clinical signals come from randomized controlled trials showing reduced severity and duration of upper respiratory tract infections (URTIs) in athletes, older adults, and people prone to seasonal illness, though the overall human evidence remains heterogeneous and more large-scale trials are still needed. Research published in PMC confirms the receptor-level mechanisms are well established in preclinical models, with promising but not yet definitive human data. Here is what the current evidence supports: Yeast/fungal β-1,3/1,6 glucans are the forms most studied for immune modulation, with a systematic review of 34 RCTs reporting immunomodulation outcomes including reduced respiratory infection symptoms a...

The strongest Viome alternatives for U.S. health-conscious adults fall into several clear categories: an RNA-focused lab (metatranscriptomics, a technology similar to Viome), a clinically paired glucose-plus-microbiome program, a deep shotgun metagenomics lab, a budget 16S provider, and a packaged interpretation service like Celluvive that pairs testing guidance with consultations and targeted supplements. Here is the shortlist at a glance: RNA-focused lab (e.g., ZOE): Combines microbiome sequencing with continuous glucose monitoring for nutrition-specific predictions. Best if personalized meal scoring is your primary goal. Clinically paired CGM + microbiome program (e.g., DayTwo): Pairs gut data with blood glucose response for metabolic and weight-management goals. Best for metabolic health and diabetes-adjacent concerns. Shotgun metagenomics lab (e.g., Ombre/Thryve): Species-level resolution without the RNA layer. Best for readers who want deeper taxonomic data at a lower price th...